PCAU started operating from the premises of Hospice Africa Uganda (HAU) and was managed by volunteers for over six years. In 2006, PCAU moved out of Hospice Africa Uganda with a seed fund of three hundred thousand shillings to carry out its activities. It had only one employee, Ms. Rose Kiwanuka. The African Palliative Care Association (APCA) then housed PCAU for four years.
In February 2010, PCAU moved into a rented house in Makindye. This helped to improve its visibility, the Ministry of Health then started to recognize its contribution to palliative care. Later in the same year, PCAU received funding from USAID to the tune of 150 million which continued annually for five consecutive years plus a vehicle (Land cruiser) through Hospice Africa Uganda.